The Responsive Amygdala: Treatment-induced Alterations in Functional Connectivity in Pediatric Complex Regional Pain Syndrome
Identifieur interne : 000071 ( Main/Exploration ); précédent : 000070; suivant : 000072The Responsive Amygdala: Treatment-induced Alterations in Functional Connectivity in Pediatric Complex Regional Pain Syndrome
Auteurs : Le Simons ; M. Pielech ; N. Erpelding ; C. Linnman ; E. Moulton ; S. Sava ; A. Lebel ; P. Serrano ; N. Sethna ; C. Berde ; L. Becerra ; D. BorsookSource :
- Pain [ 0304-3959 ] ; 2014.
Abstract
The amygdala is a key brain region with efferent and afferent neural connections
that involve complex behaviors such as pain, reward, fear and anxiety. This study
evaluated resting state functional connectivity of the amygdala with cortical and
subcortical regions in a group of chronic pain patients (pediatric complex regional pain
syndrome) with age-gender matched controls before and after intensive
physical-biobehavioral pain treatment. Our main findings include (1) enhanced functional
connectivity from the amygdala to multiple cortical, subcortical, and cerebellar regions
in patients compared to controls, with differences predominantly in the left amygdala in
the pre-treated condition (
Url:
DOI: 10.1016/j.pain.2014.05.023
PubMed: 24861582
PubMed Central: 4157948
Affiliations:
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Connectivity in Pediatric Complex Regional Pain Syndrome</title><author><name sortKey="Simons, Le" sort="Simons, Le" uniqKey="Simons L" first="Le" last="Simons">Le Simons</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Psychiatry</nlm:aff></affiliation></author><author><name sortKey="Pielech, M" sort="Pielech, M" uniqKey="Pielech M" first="M" last="Pielech">M. Pielech</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation></author><author><name sortKey="Erpelding, N" sort="Erpelding, N" uniqKey="Erpelding N" first="N" last="Erpelding">N. Erpelding</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Linnman, C" sort="Linnman, C" uniqKey="Linnman C" first="C" last="Linnman">C. Linnman</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Moulton, E" sort="Moulton, E" uniqKey="Moulton E" first="E" last="Moulton">E. Moulton</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Sava, S" sort="Sava, S" uniqKey="Sava S" first="S" last="Sava">S. Sava</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation></author><author><name sortKey="Lebel, A" sort="Lebel, A" uniqKey="Lebel A" first="A" last="Lebel">A. Lebel</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Serrano, P" sort="Serrano, P" uniqKey="Serrano P" first="P" last="Serrano">P. Serrano</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation></author><author><name sortKey="Sethna, N" sort="Sethna, N" uniqKey="Sethna N" first="N" last="Sethna">N. Sethna</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Berde, C" sort="Berde, C" uniqKey="Berde C" first="C" last="Berde">C. Berde</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Becerra, L" sort="Becerra, L" uniqKey="Becerra L" first="L" last="Becerra">L. Becerra</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author><author><name sortKey="Borsook, D" sort="Borsook, D" uniqKey="Borsook D" first="D" last="Borsook">D. Borsook</name><affiliation><nlm:aff id="A1">P.A.I.N. Group, Department of Anesthesia, Boston Children’s Hospital and Center for Pain and the Brain</nlm:aff><wicri:noCountry code="subfield">Boston Children’s Hospital and Center for Pain and the Brain</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Harvard Medical School</nlm:aff></affiliation></author></analytic><series><title level="j">Pain</title><idno type="ISSN">0304-3959</idno><idno type="eISSN">1872-6623</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The amygdala is a key brain region with efferent and afferent neural connections
that involve complex behaviors such as pain, reward, fear and anxiety. This study
evaluated resting state functional connectivity of the amygdala with cortical and
subcortical regions in a group of chronic pain patients (pediatric complex regional pain
syndrome) with age-gender matched controls before and after intensive
physical-biobehavioral pain treatment. Our main findings include (1) enhanced functional
connectivity from the amygdala to multiple cortical, subcortical, and cerebellar regions
in patients compared to controls, with differences predominantly in the left amygdala in
the pre-treated condition (<italic>disease state</italic>); (2) dampened hyperconnectivity
from the left amygdala to the motor cortex, parietal lobe, and cingulate cortex after
intensive pain rehabilitation treatment within patients with nominal differences observed
among healthy controls from Time 1 to Time 2 (<italic>treatment effects</italic>); (3)
functional connectivity to several regions key to fear circuitry (prefrontal cortex, bilateral middle temporal lobe, bilateral cingulate, hippocampus) correlated with higher pain-related fear scores and (4) decreases in pain-related fear associated with decreased
connectivity between the amygdala and the motor and somatosensory cortex, cingulate, and
frontal areas. Our data suggest that there are rapid changes in amygdala connectivity
following an aggressive treatment program in children with chronic pain and intrinsic
amygdala functional connectivity activity serving as a potential indicator of treatment
response.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Becerra, L" sort="Becerra, L" uniqKey="Becerra L" first="L" last="Becerra">L. Becerra</name><name sortKey="Berde, C" sort="Berde, C" uniqKey="Berde C" first="C" last="Berde">C. Berde</name><name sortKey="Borsook, D" sort="Borsook, D" uniqKey="Borsook D" first="D" last="Borsook">D. Borsook</name><name sortKey="Erpelding, N" sort="Erpelding, N" uniqKey="Erpelding N" first="N" last="Erpelding">N. Erpelding</name><name sortKey="Lebel, A" sort="Lebel, A" uniqKey="Lebel A" first="A" last="Lebel">A. Lebel</name><name sortKey="Linnman, C" sort="Linnman, C" uniqKey="Linnman C" first="C" last="Linnman">C. Linnman</name><name sortKey="Moulton, E" sort="Moulton, E" uniqKey="Moulton E" first="E" last="Moulton">E. Moulton</name><name sortKey="Pielech, M" sort="Pielech, M" uniqKey="Pielech M" first="M" last="Pielech">M. Pielech</name><name sortKey="Sava, S" sort="Sava, S" uniqKey="Sava S" first="S" last="Sava">S. Sava</name><name sortKey="Serrano, P" sort="Serrano, P" uniqKey="Serrano P" first="P" last="Serrano">P. Serrano</name><name sortKey="Sethna, N" sort="Sethna, N" uniqKey="Sethna N" first="N" last="Sethna">N. Sethna</name><name sortKey="Simons, Le" sort="Simons, Le" uniqKey="Simons L" first="Le" last="Simons">Le Simons</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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